To study GR activity, and the consequences thereof, across different primary cancer types, we made use of 55 in vitro experimental models that were exposed to glucocorticoids (e.g., dexamethasone (Dexa) and hydrocortisone) or vehicle (Veh), and subsequently processed for transcriptome profiling (Fig 1A; a more detailed overview can be found in Fig EV1; Details on models and public accession codes can be found in Table EV1). This evidence concerns the gene NR3C1 and cancer.