NR3C1 and cancer: Across the TCGA cohort, we show that GRa only weakly correlates with NR3C1 mRNA levels itself (Fig EV2E; R = 0.38), that is, at low ends of GR mRNA expression, the major fraction of all cancers have low GR activity, while for intermediate and high GR mRNA levels, a large variation exists between samples (Fig EV2E).