At 16 h, viral infection induced an up-regulation of GABARAPL1, MAP1LC3A, PIK3C3, USP30, and TBK1 (also up-regulated at 48 h), and a down-regulation of STK11, LARP1, ZC3H12A, TFEB, TICAM1, GOLGA2, PIK3R2, IFI16, ULK1, WDR81, SQSTM1 (also down-regulated at 48 h), and HK2. The gene discussed is PIK3C3; the disease is viral infectious disease.