LEF1 and cancer: In lung cancer cells, DACT2 inhibits the Wnt signaling pathway, preventing cancer proliferation. In addition to degrading DVL through a lysosome‐dependent pathway, DACT2 prevents LEF1 from binding to β‐catenin. As result, hypermethylation of the DACT2 promoter region leads to loss of DACT2 expression and, as a result, leads to increased expression of β‐catenin.