DAPK1 and squamous cell carcinoma: In this regard, prior studies revealed that the abnormal methylation of DAPK is exhibited in both adenocarcinomas and squamous cell carcinomas, and it should be noted that DAPK promoter hypermethylation can serve as a notable abnormal indicator of NSCLC early stage; as another example, it appears that methylated DAPK in alveolar hyperplasia of LUAD points to a role of DAPK influence during adenocarcinoma early development.128, 129