Abnormal promoter methylation of seven Wnt inhibitors (secreted frizzled related protein 1 (sFRP1), sFRP2, sFRP4, sFRP5, WIF1, Dickkopf‐3 (DKK3), and human homologue of dapper (HDPR1) is linked to the activation of the Wnt pathway in ALL resulting in the downregulation of the expression of these inhibitors. This evidence concerns the gene SFRP1 and acute lymphoblastic leukemia.