Our conclusion that these identified genes are associated with Aβ uptake, which in turn leads to poor clinical outcomes, is supported by the following observations: (1) Six genes (LCMT1, SCRN2, LRRC46, MRPL10, SP6, and OSBPL7) were associated with Aβ uptake; (2) eQTL analysis revealed that the SNPs in these genes were associated with the regulation of genes; (3) these SNPs were predictive of neurodegeneration and cognitive impairments. Here, LRRC46 is linked to Cognitive impairment.