Several genes and proteins, such as DKs and cyclins, have been linked to cell cycle dysregulation in AD (Yang et al., 2003; Hamdane and Buée, 2007; Zhang et al., 2012), and cell cycle proteins have been reported to be related to tau phosphorylation (Conejero-Goldberg et al., 2008; Seward et al., 2013; Kim et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.