However, hereditary ATTR-CM has a more heterogeneous multisystem presentation compared to ATTRwt, as the deposition of ATTR can occur in multiple organs beside the heart, most commonly the peripheral nervous system (ATTR polyneuropathy [ATTR-PN]) and autonomic nervous system, musculoskeletal system, eye, kidney, and gastrointestinal tract [30, 32, 33, 34]. This evidence concerns the gene TTR and cutaneous mastocytosis.