PTEN and cancer: It has been shown to downregulate MMP-2 and MMP-9 in glioblastomacells.35 PTEN is a tumor suppressor gene,and mutations of the PTEN gene have been detected in various cancers.TQ exerts its effect by upregulating the PTEN gene, stopping the cellcycle, and activating apoptosis, thereby inhibiting cell proliferation.37