We found that after ETBR overexpression intervention in the EAM model, myocardial tissue showed only a small amount of myocardial cell arrangement disorder and cell swelling, inflammatory cell infiltration was significantly reduced, and the myocarditis score was significantly decreased, suggesting that ETBR overexpression can reduce the inflammatory pathological damage of autoimmune myocarditis. The gene discussed is EDNRB; the disease is autoimmune myocarditis.