For instance, NTMT1 knockdown significantly enhances the sensitivity of breast cancer cell lines to both etoposide treatment and γ-irradiation, increases proliferation rate, invasive potential, anchorage-independent growth, as well as, xenograft tumor size, and tamoxifen sensitivity (Bonsignore & Butler, 2015; Dong & Mao, 2015). This evidence concerns the gene NTMT1 and neoplasm.