BCAS2 and esophageal cancer: Despite its importance, previous studies on BCAS2 gene function mainly focused on the regulation of cancer malignancy including breast cancer (Qi et al., 2005; Salmerón-Hernández et al., 2019), prostate cancer (Kuo et al., 2015) and esophageal cancer (Lang & Zhao, 2018), and there are largely unknown about its physiological roles in normal cells, particularly in germ cells.