PLXNB1 and laryngotracheoesophageal cleft: In addition, we also observed that after blocking PlexinB1, Sema4A-induced proliferative, migratory and invasive abilities as well as viability of LC cells were suppressed evidently, but blocking PlexinB2 and PlexinD1 did not always significantly inhibit Sema4A-induced proliferative, migratory and invasive abilities as well as viability for LC cells, these observations implicated that Sema4A might contribute to the development of LC by interacting with PlexinB1.