Single nucleotide polymorphisms within the human SHIP-1 gene INPP5D are strongly correlated with the development of Alzheimer’s disease and associated pathology in the aging brain (Farfel et al., 2016; Jing et al., 2016; Efthymiou and Goate, 2017; Yoshino et al., 2017; Tsai et al., 2021; Zajac et al., 2021). This evidence concerns the gene INPP5D and early-onset autosomal dominant Alzheimer disease.