While a recent study observed no changes in ERK or MAPK signaling in microglia after Inpp5d knockdown in the context of neurodegenerative disease (Iguchi et al., 2023), future investigations into how SHIP-1 deficiency affects other components of the PI3K signaling pathway in microglia after brain trauma may provide further insight into these distinct or overlapping mechanisms. The gene discussed is INPP5D; the disease is neurodegenerative disease.