INPP5D and Splenomegaly: At 12 weeks post-injury, both sham and injured SHIP-1−/− mice exhibited reduced body weight, pronounced splenomegaly, and elevated circulating cytokines and growth factors compared to SHIP-1+/− controls, confirming the previously characterized SHIP-1-deficient phenotype (Maeda et al., 2010; Tsantikos et al., 2018).