INPP5D and injury: Next, we examined the inhibitory effect of SHIP-1 in chronic glial responses by assessing microglia activation, morphology, and astrocyte reactivity in SHIP-1−/− mice at 12-weeks following pediatric brain injury, given prolonged glial activation following focal brain injuries was previously identified in pre-clinical studies (Loane et al., 2014; Figures 8 and Supplementary Table S11).