At 12-weeks post-injury, SHIP-1−/− mice had reduced body weight and exhibited splenomegaly, independent of injury, likely reflecting their known peripheral inflammatory phenotype (Figures 6A,B; Helgason et al., 1998; Liu et al., 1999; Maxwell et al., 2011; Tsantikos et al., 2018). The gene discussed is INPP5D; the disease is Splenomegaly.