Previous studies using gene deficient mice have revealed a critical regulatory role for SHIP-1 in immune cell signaling, with perturbation of the pathway resulting in inflammatory lung and gastrointestinal diseases (Helgason et al., 1998; Liu et al., 1999; Takeshita et al., 2002; Kerr et al., 2011; Maxwell et al., 2011; McLarren et al., 2011; Hibbs et al., 2018). The gene discussed is INPP5D; the disease is gastrointestinal disease.