In a separate analysis assessing the relationship between type 2 eosinophilic and non-type 2 mechanisms in patients with asthma, higher IL-6 levels tended to be positively correlated with blood neutrophil count and are thought to be a driver of non-type 2 mechanisms that can coincide with elevation of eosinophils, IgE, or nitric oxide production [8, 34]. The gene discussed is IGHE; the disease is asthma.