KDM6B and breast cancer: Exosomal miR-138-5p, which is upregulated in breast cancer, prevents the expression of histone demethylase KDM6B, which reduces the level of H3K27me3, thereby increasing the level of H3K27me3 and the transcriptional activity of genes encoding proinflammatory factors, leading to the suppression of M1 polarization (113).