EBNA1 stimulated regulatory T cell (Treg) chemotaxis towards the NPC TME, through the upregulation of the transforming growth factor-β1 (TGF-β1)-SMAD3-PI3K-AKT-c-JUN-CXCL12-CXCR4 axis and downregulation of miR-200a (229). Here, PIK3CA is linked to nasopharyngeal carcinoma.