PAX8 and adenocarcinoma: Pax-8 exhibits a remarkable capacity for recognizing the majority of adenocarcinomas within the female genital tract, a characteristic that starkly contrasts with its applicability to lung adenocarcinomas (60, 61); the positive Pax-8 immunostaining observed in our cases has significantly contributed to the precise elucidation of the diagnosis, firmly establishing the origin of the lung metastasis as stemming from EEC.