Pax-8 exhibits a remarkable capacity for recognizing the majority of adenocarcinomas within the female genital tract, a characteristic that starkly contrasts with its applicability to lung adenocarcinomas (60, 61); the positive Pax-8 immunostaining observed in our cases has significantly contributed to the precise elucidation of the diagnosis, firmly establishing the origin of the lung metastasis as stemming from EEC. Here, PAX8 is linked to lung adenocarcinoma.