Additionally, there was patchy positive staining for P16 that could help us to distinguish it from SC and EEC, while staining was negative for TTF-1 and Napsin A. The manifestation of wild-type p53 was discerned in our cases, a finding harmoniously aligned with the primary endometrioid endometrial carcinoma immunohistochemical staining. This evidence concerns the gene TP53 and endometrial endometrioid carcinoma.