CXCL8 and neoplasm: First of all, tumor cells can release a variety of inflammatory factors, such as interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor (TNF) and so on to functionally shape their microenvironment, and these factors can dilate blood vessels and attract innate immune cells and adaptive immune cells to the tumor site, which in turn cause local and systemic inflammatory responses (37).