For example, herbal melanin, extracted fromN. sativa, enhanced the production of m-RNA expression of TNF-α, and IL-6 in normal human peripheral blood mononuclear cells.32 While, it has been suggested that the treatment with TQ inhibited the production of TNF-α-induced IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts.33 This evidence concerns the gene TNF and rheumatoid arthritis.