Recent data from both Pax5+/- and ETV6-RUNX1+ mice show that the genetic predisposition is firmly associated with changes in the gut microbiome as the genetic predisposition in each case can be predicted just based on the murine gut microbiome composition, irrespective of whether the animals develop B-ALL or not (68). This evidence concerns the gene PAX5 and precursor B-cell acute lymphoblastic leukemia.