Recent studies have shown that the knockdown of B4GALT3 promotes fibroblast motility and leads to the activation of integrin beta 1 (ITGB1) via NF-κB signaling in fibroblasts, which promotes the development of lung metastases from HCC through the secretion of IL-6 and IL-8 (22). This evidence concerns the gene ITGB1 and hepatocellular carcinoma.