Besides NLGN3, brain-derived neurotrophic factor (BDNF) and 78-kDa glucose-regulated protein (GRP78) were also identified as possible activity-regulated glioma mitogens (55).Another study by the same group, showed that the synaptic and electrical integration of glioma cells into neural circuits promotes the progression of these cells. The gene discussed is HSPA5; the disease is central nervous system cancer.