Pseudoallergy differs from other reactions associated with food intolerance (defects or absence of digestive enzymes, psychoemotional intolerance) in that the same mediators are involved in its manifestation as in true food allergies (histamine, leukotrienes, prostaglandins, cytokines) albeit they are released from allergy target cells in a nonspecific way, that is, without the participation of IgE or other allergic antibodies. Here, IGHE is linked to allergic disease.