Additionally, several other immunologically relevant pathways were modulated by SS (PKCθ, OX40, CTLA4, PDL1/PD1, Nur77, DC maturation) as well as pathways relevant to CSC maintenance (Molecular Mechanisms of Cancer, Hypoxia, PI3K/AKT, Wnt, ERK5), all of which cross-talk with Notch. The gene discussed is CTLA4; the disease is cancer.