Furthermore, in gliomas, which include GBM and LGG, ORC6 expression was negatively correlated with the abundance of infiltrating immune cells, including Tem CD8, Tcm CD4, Tfh, Th1, Th17, Act B, lmm B, NK, MDSC, NKT, Act DC, pDC, iDC, macrophage, eosinophil, mast, monocyte, and neutrophil cells. Here, CD4 is linked to central nervous system cancer.