CHMP5 and COVID-19: To directly evaluate the degree of T cell cross-reactivity against immunodominant antigens from SARS-CoV-2 and hCoVs, we primed and expanded PBMCs from donors (n=7, five HCW and two IP subjects) with documented history of COVID-19 using the panel of Spike (S1 plus S2), NP and M pepmixes derived from each of the coronavirus included in the study.