CYBB and Sepsis: According to the results of our drug prediction analysis, we identified three drugs predicted to target both FCAR and CYBB (Figure S8): 3,4,5,3,4’-pentachlorobiphenyl, antirheumatic agent, and sulforaphane(SFN), of which 3,4,5,3,4’-pentachlorobiphenyl is listed as a class 1 carcinogen by the World Health Organization, while antirheumatic drugs and SFN have potential to contribute to improvement of survival in patients with sepsis in the future.