Verification analysis of the seven core genes in GSE145227 demonstrated that the expression of MMP9, SLC22A4, FCAR, PADI4, and S100A12 differed significantly between the sepsis and healthy groups, and all of them showed an increasing trend; however, levels of CYBB and DNASE1 did not differ significantly between the groups. The gene discussed is PADI4; the disease is Sepsis.