To examine whether the survival-associated genes, CYBB and FCAR, have value for prediction of clinical features in sepsis, we constructed survival prediction models including patient sex, age, pneumonia, thrombocytopenia, ICU-acquired pneumonia, diabetes, and abdominal sepsis, as well as CYBB and FCAR expression levels; these multiple factors were combined to predict the survival of patients with sepsis in ICU. This evidence concerns the gene CYBB and Sepsis.