Among the top 14 up-regulated extracellular protein-encoding genes in the sepsis and control groups that had the highest logFC values were S100A8, IL6, MMP8, S100A9, CSF3, S100A12, FCGR3B, CD177, FCN1, ATP6V0A4, CXCL3, SLURP1, CXCL11, and LY96 (Figure 3B). This evidence concerns the gene MMP8 and Sepsis.