ACAT1 and neoplasm: The AVA-mediated ACAT-1 inhibitionprevented cellular cholesterol esterification and improved cholesterollevels on the T cell membrane, thus enhancing antitumor immunity.In addition, inhibition of ACAT-1 in tumor cells limited the migrationof tumor cells and synergized with PPa-mediated PDT to elicit a strongantitumor immune response in melanoma and breast tumor models.