CD274 and neoplasm: Likewise, a mannosylated lactoferrin nanocomposite (Man-LFNPs) was constructed to alleviate the immunosuppressive TMME by dual-targetedcodelivery of PD-L1 inhibitor (JQ1) and shikonin (Table 2).68 Notably, the lactoferrin (an iron-carrying protein) of the resultantnanomedicine selectively bound to the overexpressed low-density lipoproteinreceptor-related protein 1 (LRP-1) on tumor vascular endothelial cellsand tumor cells.