This modulation of cellularmetabolism significantly reduced the level of M2-like TAMs and enhancedthe infiltration of cytotoxic CD8+ Teff cells in tumortissues (Figure 4B).In vivo experiments revealed that α-T-K not only inhibited the4T1 breast tumor growth but also synergistically enhanced the therapeuticeffect of PD-1 antibody-based immunotherapy in Lewis lung carcinoma(LLC) mice. Here, PDCD1 is linked to breast neoplasm.