XBP1 and neoplasm: Hyperactivated X-box binding protein 1 (XBP1) and a highintracellular ROS concentration within tumor-infiltrating DCs (TIDCs)can promote intracellular accumulation of peroxidized lipids, whichresult in poor T-cell priming and activation.159 However, it remains a major hurdle to achieving directpharmacological inhibition of nuclear XBP1.