To circumvent this issue, Mao et al. developed ananotechnology-assisted combinatorial therapy that can promote ROS-inducedICD and concurrently overcome adenosine-mediated tumor immunosuppression(Figure 12A, Table 5).182 In this study, a nanomedicine (NP700-ARL) was fabricatedby coself-assembly of boronic acid (BA)-containing cationic polymer,CD39/CD73 inhibitor (ARL67156), and PS (IR700)-containing lipid polymer.In this nanocomposite, the anionic nucleotide ARL67156 was linkedwith BA to form an ROS-labile covalent conjugate through electronicinteractions and phenylboronic ester. This evidence concerns the gene NT5E and neoplasm.