In this context, Wang et al. devised a H2O2-responsive coassembled nanomedicine (CAT-NP) that encapsulateda camptothecin (CPT) prodrug (CPT-S-PEG), A2AR antagonist (AZD4635),and NIR-II molecule (TST) with aggregation-induced emission (AIE)properties (Table 5).188 In the presence of high concentrationsof H2O2 within tumor cells, CPT was activatedand released from CAT-NP, thereby promoting the release of TST andAZD4635 by inducing the disassembly of CAT-NP. The gene discussed is ADORA2A; the disease is neoplasm.