In this regard, Jia et al. developed GSHand pH dual-responsive mPEG-PLA-PHis-ss-PEI polyplexes (DRP/Res/siP)encapsulating PD-L1 siRNA and resveratrol (Table 2).70 This nanomedicinepromoted ICB-based immunotherapy by simultaneously regulating theglycolysis and the OXPHOS of tumor cells. This evidence concerns the gene CD274 and neoplasm.