The activation of the nutrient-sensing mammaliantarget of rapamycin(mTOR) signaling pathway not only stimulates the uptake of glucoseand promotes glycolysis but also facilitates the polarization of TAMstoward M2-like phenotypes by upregulating p-STAT3and IL-10.99,100 Moreover, angiogenesis playsa critical role in regulating tumor metabolism and antitumor immuneresponses as dysregulated vasculature results in tumor hypoxia andacidosis. Here, MTOR is linked to neoplasm.