Lactate oxidase (LOX), a catalytic enzyme capableof convertinglactate into H2O2 and pyruvate, offers a potentialstrategy for removing intratumoral lactate.83 Recently, He et al. designed a “nanofactory” for synergisticCDT and lactate-trapping-mediated tumor metabolic reprogramming (Table 2).84 The nanofactory (PLNPCu) was constructed byencapsulating LOX and Cu2+ in a cationic PEI-based nanoassemblythrough electrostatic interaction and coordination. This evidence concerns the gene LOX and neoplasm.