PDK1 and neoplasm: Therefore,it is urgently needed to develop therapeutic strategies that can preferentiallytarget and inhibit glycolysis in tumor cells while sparing TIICs.The highly expressed pyruvate dehydrogenase kinase 1 (PDK1) in mitochondriaplays a crucial role in regulating tumor glycolysis, representinga promising target for glycolysis inhibition in cancer cells.76 The therapeutic efficacy of dichloroacetate(DCA, a PDK1 inhibitor) was hindered by limited cellular uptake andinadequate mitochondrial localization.