Of note, the byproduct H2O2 produced by LOX-mediated lactate metabolism can reactwith a chemiluminescence reagent (bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl]oxalate,CPPO), subsequently releasing energy capable of activating the photosensitizer.Therefore, Lu et al. constructed a glioma cell-biomimetic nanomedicine(M@HLPC) to achieve a synergistic combination of lactate metabolictherapy and chemiexcited PDT (Figure 3C, Table 2).85 This nanomedicine was fabricatedby coself-assembly of hemoglobin, LOX, CPPO, and Ce6, followed bycloaking of membranes from glioma cells. The gene discussed is LOX; the disease is central nervous system cancer.