Besides, the expression of PD-L1 on tumor cellswas significantly downregulated in the ArgNP plus anti-PD-L1 treatmentgroup (Figure 8C).In vivo studies revealed that ArgNP synergized anti-PD-L1 to significantlyinhibit tumor growth and prolong the survival time of 4T1 tumor-bearingmice (Figure 8D). Here, CD274 is linked to neoplasm.