CNR2 and neoplasm: However, MGLL downregulationcan promote the polarization of M2-like TAMs via 2-arachidonoylglycerol(2-AG)-mediated endocannabinoid receptor-2 (CB-2) activation.157 To overcome this obstacle, a GSH-activatablenanomedicine was developed to concurrently inhibit tumor lipid metabolismand M2-like TAMs polarization (Figure 10A, Table 4).158 This nanomedicinewas constructed by encapsulating MGLL siRNA (siMGLL) and CB-2 siRNA(siCB-2) in poly(disulfide amide) (PDSA)-based NPs.