In order to implement nanomedicine-enabled combinationtherapy, Chen et al. prepared a versatile nanocage (GSZMP) by loadingsiRNA-targeting IDO (siIDO) and gemcitabine (GEM) into MnO2-mineralized ZIF-8 NPs, followed by surface modification with anti-PD-L1 (Figure 7A, Table 3).131 The tumor-enriched H+ and H2O2 triggered the disintegration of the mineralizedMnO2 shell to generate O2, which repolarizedM2-like TAMs toward M1-like phenotypes. Here, CD274 is linked to neoplasm.