Another urea-based PSMA inhibitor analogue, PSMA-I&S (Robu et al., 2017), when radiolabeled with 99mTc, has been used in the intrasurgery identification of metastatic lymph nodes, with confirmed applicability in radioguided surgery of PCa and potential to be also used as a SPECT imaging alternative to the PET-based radiopharmaceuticals. The gene discussed is FOLH1; the disease is posterior cortical atrophy.