Subsequent [99mTc]Tc-PSMA-I&S SPECT/CT imaging (Figures 7B,D), conducted 2 h after radiopharmaceutical administration, confirmed the presence of a PSMA-avid primary prostate tumor and left internal iliac lymph node metastasis, in concordance with the findings from the [68Ga]Ga-PSMA-11 PET/CT scan. The gene discussed is FOLH1; the disease is prostate neoplasm.