The experimental outputs of our study are certainly elaborate, but we think that it is crucial to compare the effects of Aβ and P-tau (as well as their combination) in similar conditions, and to test the effects of Epo-D under these same conditions (as well as under physiological conditions), to fully model and understand the complexity of AD found in clinical settings (Ranasinghe et al., 2022). Here, MAPT is linked to Alzheimer disease.