In the unilateral ureteral obstruction (UUO) model (Lee et al., 2023), Piezo1 deletion was observed followed by a crucial reduction in the CCL2-CCR2 signaling pathway and Notch pathway (He et al., 2022a), which inhibited the inflammation of macrophages and the progression of renal fibrosis. The gene discussed is CCR2; the disease is renal fibrosis.