First, after high-pressure acts on pancreatic alveolar cells, Piezo1 channels open and calcium ions flow inward into the cells, but some experiments have found that the opening of Piezo1 channels can only trigger transient calcium ion inward flow, which is not enough to cause pancreatitis, so only after prolonged high pressure acts on alveolar cells, Piezo1 channels open, inducing PLA2 channel activation, and then inducing TRPV4 channel opening, which eventually allows a continuous inward flow of calcium ions (Romac et al., 2018; Swain et al., 2020; Gorelick and Nathanson, 2020). The gene discussed is PIEZO1; the disease is pancreatitis.