When the pancreas is subjected to external mechanical injury, Piezo1 pathologically opens continuously, calcium ions flow in a large amount, intracellular calcium ion homeostasis is disrupted, and intracellular zymogen and lysosomal particles in the pancreatic follicle cells react abnormally, and lead to pancreatitis (Geokas et al., 1985; Tenner et al., 2013; Mayerle et al., 2019). The gene discussed is PIEZO1; the disease is pancreatitis.