TNF and pancreatitis: PSCs express Piezo1, which is activated by the continuous action of high pressure on PSCs, secreting interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and other cellular inflammatory factors, which can accelerate the damage of alveolar cells and lead to pancreatitis complicated by pancreatic fibrosis (Talukdar and Tandon, 2008; Piao et al., 2015; Hao et al., 2017).