Piezo1 is a mechanosensitive calcium channel, and immunohistochemical staining revealed widespread Piezo1 expression in mouse pulmonary tissues (Zhang Y. A. et al., 2021), epithelial cells, and endothelial cells (Zhong et al., 2018; Friedrich et al., 2019; Bhattacharya and Hough, 2019), and was suggested to play an important role in bleomycin-induced pulmonary fibrosis (Solis et al., 2019a; Solis et al., 2019b). Here, PIEZO1 is linked to pulmonary fibrosis.