Piezo1 can induce ATP release during the mechanical stretch, and the released ATP can, in turn, drive mechanical stretch to enhance EMT, thus exacerbating pulmonary fibrosis (Diem et al., 2020; Fang et al., 2022), and leading to more severe pulmonary fibrosis in ARDS during ventilation. Here, PIEZO1 is linked to pulmonary fibrosis.