Jia-Qi Huang and his colleagues discovered through cell line studies and cell culture of rat lung cells that a positive response mechanism for the relationship of Piezo1 to TGF-β1 was found to exist in radiation-induced pulmonary fibrosis (Huang et al., 2021a) and has a critical role in the radiation-induced generation of EMT. This evidence concerns the gene TGFB1 and pulmonary fibrosis.