The mechanical signal was delivered to ECM with calcium inward flow, activation of calpain2, which signals downstream of Piezo1, induces talin1 clearance and upper-regulation of integrin β1 protein (Bate et al., 2012; Zhao X. et al., 2022), and integrin and ECM bind more tightly and induce the development of renal fibrosis. Here, PIEZO1 is linked to renal fibrosis.