PIEZO1 and renal fibrosis: One investigator created a genetically engineered mouse model (He et al., 2022a) that specifically knocked out Piezo1 from bone marrow cells, intending to study the mechanism of the mechanosensitive protein Piezo1 in renal fibrosis, and finally found that mice with Piezo1 knockout alleviates renal fibrosis, suggesting that the development of targeting Piezo1 mechanical channels offers a possible approach to the management of renal fibrosis (He et al., 2022a; Zhao X. et al., 2022).