PIEZO1 and renal fibrosis: Recent research revealed that Piezo1 expressed markedly elevated in fibrotic kidneys, and treatment of the UUO model with GsMTx4, a blocker of Piezo1 (Velasco-Estevez et al., 2020), revealed a significant attenuation of renal fibrosis, indicating that Piezo1 has an essential function in renal fibrosis (Zhao X. et al., 2022).