In the unilateral ureteral obstruction (UUO) model (Lee et al., 2023), Piezo1 deletion was observed followed by a crucial reduction in the CCL2-CCR2 signaling pathway and Notch pathway (He et al., 2022a), which inhibited the inflammation of macrophages and the progression of renal fibrosis. Here, PIEZO1 is linked to renal fibrosis.