PKD1 and hereditary disease: In the 2000s, polycystin-1 and polycystin-2 proteins (mechanosensory complex), encoded by the causative genes PKD1 and PKD2 of polycystic kidney disease (PKD) (Pazour et al., 2002; Yoder et al., 2002; Masyuk et al., 2014), a genetic disorder, gained attention due to their specific presence in the primary cilia of renal tubular epithelial cells (Guay-Woodford, 2003; Davenport and Yoder, 2005).