CRP testing using a cutoff of ≥80 mg/l, integrated into an electronic decision algorithm, was able to improve clinical outcome in children with respiratory infections while substantially reducing antibiotic prescription in primary care centers in Tanzania.2.3% children in the intervention arm vs. 40.4% in the control arm received antibiotics at day 0 (RR, 0.06). There were fewer secondary hospitalizations and deaths in the CRP arm: 0.5% vs. 1.5% (RR, 0.30). This evidence concerns the gene CRP and respiratory tract infectious disorder.