In the linear mixed-effect model, which tested the effect of the ACE I/D genotype × time interaction on changes in CMB counts, the DD carriers had a much greater increase in total CMB counts than the ID/II carriers after adjusting for the baseline number of CMBs, age, sex, and HTN (estimated mean of difference [standard error (SE)] = 1.33 [0.61]; p = 0.03) (Table 2). The gene discussed is ACE; the disease is hypertensive disorder.