We hypothesize these laminar distributions may also influence the more widespread spread of tau pathology to dorsolateral cortices across frontal, temporal, and parietal lobes typically associated with PiD (38, 69, 70) in contrast to the relatively focal involvement of left medial and ventral frontotemporal regions characteristic of TDP-C pathology (19, 31, 71, 72). Here, MAPT is linked to pelvic inflammatory disease.