In CMT demyelinating phenotypes, genes that encode for proteins related to SC function, such as myelin components (PMP2, PMP22, and MPZ), transcription factors (EGR2/Krox20), proteins that play a role in degradation pathways (LITAF/SIMPLE), extracellular matrix (FBLN5), or adhesion molecules (GJB1/CX32 and PRX) are affected (Street et al., 2003; Punetha et al., 2018). This evidence concerns the gene PMP22 and Charcot-Marie-Tooth disease.