Given the increased lumen stenosis in PACAP−/−/ApoE−/− mice after 30 weeks of standard chow (SC), which we have demonstrated in this study (3.8-fold; p = 0.024) (Figures 1A,C–F) as well as in a recent study (29), we also investigated the effects on media thickness and body weight of PACAP deficiency in ApoE−/− mice. Here, APOE is linked to hyperinsulinemic hypoglycemia, familial, 4.