KLK3 and cancer: The objectives were: following MRI, compare biopsy rate when referred with raised PSA and abnormal DRE alone; compare the combined diagnostic yield of having an MRI and prostate biopsy (if indicated) when referred with raised PSA and abnormal DRE alone; evaluate patients referred with abnormal DRE alone with cancer to determine the cancer location, grade, and treatment; consider with an adjusted BTiPP, how many additional outpatient appointments would be required, and how many MRIs might be avoided.