The role of DS critical region in tumor suppression is strongly supported by studies using animal models, although the contribution of the individual genes, including DYRK1A, remains to be further investigated (Sussan et al., 2008; Reynolds et al., 2010; Yang and Reeves, 2011; Lee et al., 2013; Shin et al., 2014). Here, DYRK1A is linked to neoplasm.