At least in some tumor types, such as the primary ovarian cancer spheroids and gastrointestinal stromal tumors (GIST), the pro-survival role of DYRK1A is mediated by promoting the DREAM complex formation and entry into G0/G1 arrest (Boichuk et al., 2013; MacDonald et al., 2017). Here, DYRK1A is linked to gastrointestinal stromal tumor.