On the other hand, the overexpression of DYRK1A in the DS-specific B-cell acute lymphoblastic leukemia (B-ALL) and acute megakaryoblastic leukemia (AMKL) has been shown to target distinct cellular pathways (Malinge et al., 2012; Lee P. et al., 2016). Here, DYRK1A is linked to acute megakaryoblastic leukemia.