Identification of the genes on ch21 that contribute to DS-associated phenotypes support the involvement of DYRK1A imbalance in the multisystem manifestations of this syndrome, including abnormal neurological development and neurodegeneration (reviewed in (Park et al., 2009; Stringer et al., 2017; Stagni et al., 2018)). Here, DYRK1A is linked to Dravet syndrome.