The prognostic significance of BRAF mutations has been widely controversial as some studies have found that BRAF-mutated melanomas may be associated with worse survival and higher risk of recurrence but other studies have shown no survival difference compared to BRAF wild-type (Meckbach et al., 2014; Adler et al., 2017; Ny et al., 2020; Naimy et al., 2023). This evidence concerns the gene BRAF and melanoma.