Keratin, type I cytoskeletal 17 (KRT17), heat shock-related 70 kDa protein 2 (HSPA2), and keratin, type I cytoskeletal 14 (KRT14) have lower expressions, whereas complement factor B (CFB) and Rab GDP dissociation inhibitor alpha (GDI1) have higher expressions in breast cancer patients than in normal healthy controls, but on NVA-IT treatment, these proteins showed reversed expressions in MDA MB-231 cells. The gene discussed is GDI1; the disease is breast cancer.