TP53 and microcephaly: Importantly, P53 activation has been observed in a variety of microcephaly models (Frank et al., 2000; Gao, et al., 2000; McConnell et al., 2004; Insolera et al., 2014; Marjanovic et al., 2015; Ghouzzi et al., 2016; Mao et al., 2016; Bianchi et al., 2017; Sgourdou et al., 2017; Little and Dwyer, 2019; Shi et al., 2019; Phan et al., 2021; White et al., 2021; Martins et al., 2022; Peek et al., 2022; Sterling et al., 2023).