TP53 and microcephaly: In some studies, genetic deletion of Trp53 rescues cortical size, suggesting that P53 activation triggers extensive cortical cell death that leads to microcephaly (Insolera et al., 2014; Marjanovic et al., 2015; Mao et al., 2016; Bianchi et al., 2017; Little and Dwyer, 2019; Shi et al., 2019; Phan et al., 2021; Peek et al., 2022; Sterling et al., 2023).