ESR1 and colorectal carcinoma: We subsequently recognized the subtype-specific CRC TF modules, i.e., C1: FOXA1, SREBF1, ESR1, and MYB; C2: FOXA1, SREBF1; C3: FOXA1, SREBF1, and ESR1; C4: SOX4, USF1, and MYBL2; and C5: FOXA1 (Supplementary Figure S5A).