Besides, the CRC subtypes were significantly enriched in the PAM50 subtypes {Luminal A [LumA], Luminal B [LumB], Her2-enriched [Her2+], Basal-like, and Normal-like (Perou et al., 2000; Sørlie et al., 2001)} based on the accumulative hypergeometric distribution. The gene discussed is ERBB2; the disease is colorectal carcinoma.