CAPN3 and muscular dystrophy, limb-girdle, autosomal dominant 4: Recently, heterozygous mutations in the CAPN3 gene were identified as the cause of autosomal dominant limb-girdle muscular dystrophy-4 (LGMDD4), with a later onset and milder phenotype (Vissing et al., 2016; Martinez-Thompson et al., 2018a; b), although the pathogenicity of these cases remains elucidated (Sáenz and López de Munain, 2017).