TP53 and cancer: The downregulated genes such as CXCL8, CXCL10, CXCL11, CDC20, CDK6, CDKN2A, CXCL13, and SHC4 (Table 10) were enriched in chemokine signaling pathway, toll-like receptor signaling pathway, cell cycle, bladder cancer, IL-17 signaling pathway, cellular senescence, p53 signaling pathway, and microRNAs in cancer (Figure 5B).