On the other hand, the downregulated DEGs were mainly enriched in CXCR3 and CXCR chemokine receptor binding, chemokine and cytokine activity, peptidase inhibitor activity, L-leucine transmembrane transporter activity, and chitinase activity, which indicate suppressed immune system response and increased abnormal proteins which may result in cancer progression and development (Figure 3B; Table 6). This evidence concerns the gene CXCR3 and cancer.