Moreover, the downregulated DEGs of cellular components show intermediate filament, intermediate filament cytoskeleton, polymeric cytoskeletal fiber, spindle, cornified envelope, desmosome, and endoplasmic reticulum lumen, which indicate cancer development and progression due to disrupted cytoskeletal proteins, dysregulated cell division, misfolded proteins, and DNA damage (Figure 4B; Table 8). The gene discussed is DNM2; the disease is cancer.