We noticed that the “AKT signaling” (R-HSA-1257604) pathway is enriched in the DNMT1 core module, and it is worthwhile to mention that AKT signaling is crucial for T-cell differentiation and it encourages naive CD4 T cells to differentiate into Th17 to prevent oral candidiasis (Tasaki et al., 2018; Abdullah et al., 2021). The gene discussed is CD4; the disease is oral candidiasis.