Subsequently, it was traced that they are mostly involved in the “positive regulation of endocytosis” (GO:0045807) biological function and “Clathrin-mediated Endocytosis” (R-HSA-8856828) pathway (Figure 4), which is a prerequisite step for the internalization and identification of the hyphal form of C. albicans during oral candidiasis (Swidergall and Filler, 2017), and in response to that, the host activates the NF-κB, mTOR, and Akt pathway to prevent cellular damage (Moreno-Ruiz et al., 2009; Moyes et al., 2015; Netea et al., 2015). Here, AKT1 is linked to oral candidiasis.