Using a mouse model, Li et al. (2018) observed that H19 expression in the bile ducts of mice with cholestatic liver disease differed based on sex and that H19 expression was higher in multidrug resistance gene 2 knockout (Mdr2−/−) female mice with severe cholestasis than in age-matched Mdr2−/− male mice. The gene discussed is H19; the disease is cholestasis.