These NASH liver organoids showed the appearance of cells with dendritic-like morphology and the increased expression of liver fibrosis-related genes such as Collagen type I alpha 1 (Col1a1), Actin alpha 2 (Acta2), and others (Elbadawy et al., 2020a). The gene discussed is ACTA2; the disease is metabolic dysfunction-associated steatohepatitis.