LEP and obesity due to melanocortin 4 receptor deficiency: A similar response has been observed in receptors of other hypothalamic peptides involved in feeding behaviour like the leptin receptor (ObRb) in hypothalamic cells (35) as well as in animal models of obesity in which, for example, increased circulating leptin levels with higher gene expression of hypothalamic ObRb suggest desensitization of its functionality as the expression of downstream feeding peptides is also altered (36, 37).