Interestingly, our analysis of prostate cancer (DKFZ, Cancer Cell 2018) showed a significant negative correlation between SPDEF transcripts and Gleason score; patients with higher Gleason scores showed significantly reduced levels of SPDEF (n=119, r=0.4667, p<0.0001, Figures 1D, E). The gene discussed is SPDEF; the disease is Familial prostate cancer.