Compared with those who were not overweight or obese, PLWH who were overweight or obese were more likely to have hyperglycemia (aOR 1.84, 95% CI: 1.37–2.49 for overweight; aOR 2.68, 95% CI: 1.62–4.44 for obesity), higher ALT level (aOR 2.70, 95% CI: 2.33–3.13 for overweight; aOR 3.85, 95% CI: 2.93–5.05 for obesity), higher TG levels (aOR 1.89, 95% CI 1.63–2.19 for overweight; aOR 2.56, 95% CI 1.97–3.32 for obesity), and lower HDL levels (aOR 1.67, 95% CI 1.44–1.95 for overweight; aOR 2.06, 95% CI 1.54–2.77 for obesity). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.